{"id":2622,"date":"2019-02-19T17:12:30","date_gmt":"2019-02-19T16:12:30","guid":{"rendered":"https:\/\/drluismadero.com\/pediatric-oncology\/research\/"},"modified":"2019-02-19T17:56:15","modified_gmt":"2019-02-19T16:56:15","slug":"research","status":"publish","type":"page","link":"https:\/\/drluismadero.com\/en\/pediatric-oncology\/research\/","title":{"rendered":"RESEARCH"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"2622\" class=\"elementor elementor-2622 elementor-173 elementor-bc-flex-widget\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-4ba752e7 elementor-section-stretched elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"4ba752e7\" data-element_type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;,&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-f8f0d34\" data-id=\"f8f0d34\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-509204d2\" data-id=\"509204d2\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-165d44e0 elementor-widget elementor-widget-spacer\" data-id=\"165d44e0\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3d865ee elementor-widget elementor-widget-image\" data-id=\"3d865ee\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"250\" height=\"13\" src=\"https:\/\/drluismadero.com\/archivos\/img\/2018\/04\/l-madero-250x13.png\" class=\"attachment-large size-large wp-image-2505\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a4e707c elementor-widget elementor-widget-heading\" data-id=\"a4e707c\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">RESEARCH<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-13c8d584 elementor-widget elementor-widget-heading\" data-id=\"13c8d584\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Dr. Luis Madero<br\/>leads cancer research at <br\/>Children\u2019s University Hospital \u201cNi\u00f1o Jes\u00fas\u201d, Madrid<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-589c18d3 elementor-widget elementor-widget-text-editor\" data-id=\"589c18d3\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>University Hospital \u201cNi\u00f1o Jes\u00fas\u201d is a national and international reference center for the diagnosis and treatment of children with cancer. Some of the research areas include childhood leukemia, cell and oncolytic immunotherapy for metastatic or refractory pediatric tumors, physical exercise in children with cancer, cell therapy with mesenchymal cells, and the development of new targeted therapies.<\/p>\n<p>These translational research projects are funded by competitive national and international grants. Over the last ten years, a steady level of scientific output and funding has been maintained.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-2f58ced elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"2f58ced\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-bfc4af5\" data-id=\"bfc4af5\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-fccf34b elementor-view-default elementor-position-top elementor-mobile-position-top elementor-widget elementor-widget-icon-box\" data-id=\"fccf34b\" data-element_type=\"widget\" data-widget_type=\"icon-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\t\t\t<div class=\"elementor-icon-box-icon\">\n\t\t\t\t<a href=\"#lineas\" class=\"elementor-icon elementor-animation-grow\" tabindex=\"-1\" aria-label=\"RESEARCH&lt;BR\/&gt;AREAS\">\n\t\t\t\t<i class=\"fa fa-flask\" aria-hidden=\"true\"><\/i>\t\t\t\t<\/a>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<a href=\"#lineas\" >\n\t\t\t\t\t\t\tRESEARCH<BR\/>AREAS\t\t\t\t\t\t<\/a>\n\t\t\t\t\t<\/span>\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-27a1f7f\" data-id=\"27a1f7f\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a8760db elementor-view-default elementor-position-top elementor-mobile-position-top elementor-widget elementor-widget-icon-box\" data-id=\"a8760db\" data-element_type=\"widget\" data-widget_type=\"icon-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\t\t\t<div class=\"elementor-icon-box-icon\">\n\t\t\t\t<a href=\"#proyectos\" class=\"elementor-icon elementor-animation-grow\" tabindex=\"-1\" aria-label=\"RESEARCH&lt;BR\/&gt;PROJECTS\">\n\t\t\t\t<i class=\"fa fa-folder-open\" aria-hidden=\"true\"><\/i>\t\t\t\t<\/a>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<a href=\"#proyectos\" >\n\t\t\t\t\t\t\tRESEARCH<BR\/>PROJECTS\t\t\t\t\t\t<\/a>\n\t\t\t\t\t<\/span>\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-e866f75\" data-id=\"e866f75\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ceb9607 elementor-view-default elementor-position-top elementor-mobile-position-top elementor-widget elementor-widget-icon-box\" data-id=\"ceb9607\" data-element_type=\"widget\" data-widget_type=\"icon-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\t\t\t<div class=\"elementor-icon-box-icon\">\n\t\t\t\t<a href=\"#ensayos\" class=\"elementor-icon elementor-animation-grow\" tabindex=\"-1\" aria-label=\"CLINICAL&lt;BR\/&gt;TRIALS\">\n\t\t\t\t<i class=\"fa fa-eyedropper\" aria-hidden=\"true\"><\/i>\t\t\t\t<\/a>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<a href=\"#ensayos\" >\n\t\t\t\t\t\t\tCLINICAL<BR\/>TRIALS\t\t\t\t\t\t<\/a>\n\t\t\t\t\t<\/span>\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-6653abf1 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6653abf1\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-48667a95\" data-id=\"48667a95\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-0f98272 elementor-widget elementor-widget-image\" data-id=\"0f98272\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"350\" height=\"197\" src=\"https:\/\/drluismadero.com\/archivos\/img\/2018\/04\/3.png\" class=\"attachment-large size-large wp-image-2508\" alt=\"\" srcset=\"https:\/\/drluismadero.com\/archivos\/img\/2018\/04\/3.png 350w, https:\/\/drluismadero.com\/archivos\/img\/2018\/04\/3-300x169.png 300w\" sizes=\"(max-width: 350px) 100vw, 350px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-5d03f79a\" data-id=\"5d03f79a\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-22283b21 elementor-section-stretched elementor-section-content-top elementor-reverse-mobile elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"22283b21\" data-element_type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;,&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-541daa3b\" data-id=\"541daa3b\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7e993aa1 elementor-widget elementor-widget-video\" data-id=\"7e993aa1\" data-element_type=\"widget\" data-settings=\"{&quot;show_image_overlay&quot;:&quot;yes&quot;,&quot;image_overlay&quot;:{&quot;url&quot;:&quot;https:\\\/\\\/drluismadero.com\\\/archivos\\\/img\\\/2017\\\/12\\\/elm.jpg&quot;,&quot;id&quot;:1365,&quot;size&quot;:&quot;&quot;},&quot;youtube_url&quot;:&quot;https:\\\/\\\/youtu.be\\\/HRiayVPkG98&quot;,&quot;video_type&quot;:&quot;youtube&quot;,&quot;controls&quot;:&quot;yes&quot;}\" data-widget_type=\"video.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-wrapper elementor-open-inline\">\n\t\t\t<div class=\"elementor-video\"><\/div>\t\t\t\t<div class=\"elementor-custom-embed-image-overlay\" style=\"background-image: url(https:\/\/drluismadero.com\/archivos\/img\/2017\/12\/elm.jpg);\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-custom-embed-play\" role=\"button\" aria-label=\"Play Video\" tabindex=\"0\">\n\t\t\t\t\t\t\t<i aria-hidden=\"true\" class=\"eicon-play\"><\/i>\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-1a0e720b\" data-id=\"1a0e720b\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-44a0e29 elementor-widget elementor-widget-image\" data-id=\"44a0e29\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"250\" height=\"13\" src=\"https:\/\/drluismadero.com\/archivos\/img\/2018\/04\/l-madero-250x13.png\" class=\"attachment-large size-large wp-image-2505\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3e29d20 elementor-widget elementor-widget-heading\" data-id=\"3e29d20\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">RESEARCH<br\/>AND CHILDHOOD<br\/>LEUKEMIA<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-4f383031 elementor-section-full_width elementor-section-stretched elementor-section-height-default elementor-section-height-default\" data-id=\"4f383031\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;stretch_section&quot;:&quot;section-stretched&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-6115875\" data-id=\"6115875\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-49682376 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"49682376\" data-element_type=\"widget\" id=\"proin\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"titu\">\n<h2 class=\"min\"><span style=\"font-size: 30px; font-weight: 300;\">RESEARCH<\/span><\/h2>\n<h2 class=\"may\">AREAS<\/h2>\n<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-6a8fc548\" data-id=\"6a8fc548\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b17ea8d elementor-widget elementor-widget-menu-anchor\" data-id=\"b17ea8d\" data-element_type=\"widget\" data-widget_type=\"menu-anchor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-menu-anchor\" id=\"lineas\"><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-96aca46 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"96aca46\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-3d24e72\" data-id=\"3d24e72\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5455bb96 elementor-widget elementor-widget-text-editor\" data-id=\"5455bb96\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>CHILDHOOD ACUTE LEUKEMIA<\/strong>:<\/p>\n<ul>\n<li>Molecular diagnosis of minimal residual disease<\/li>\n<li>Cell adhesion molecules, cell migration pathways and clinical relevance (1)<\/li>\n<li>Identifying and validating relapse biomarkers for acute lymphoblastic leukemia (2)<\/li>\n<\/ul>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cbee068 elementor-widget elementor-widget-text-editor\" data-id=\"cbee068\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<pre>(1) Research area funded by    <a href=\"http:\/\/www.asociacionpablougarte.es\/\" target=\"_blank\" rel=\"noopener\"><img decoding=\"async\" class=\"alignnone size-full wp-image-1616\" src=\"https:\/\/drluismadero.com\/archivos\/img\/2018\/02\/logo-apu.png\" alt=\"\" width=\"129\" height=\"50\" \/><\/a><\/pre>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a71736d elementor-widget elementor-widget-text-editor\" data-id=\"a71736d\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<pre>(2) Research area funded by        <a href=\"https:\/\/unoentrecienmil.org\/\" target=\"_blank\" rel=\"noopener\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-1620\" src=\"https:\/\/drluismadero.com\/archivos\/img\/2018\/02\/unoentrecienmil-logo50.png\" alt=\"\" width=\"50\" height=\"50\" \/> <\/a><\/pre>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-0e29f78 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"0e29f78\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-5f18b72\" data-id=\"5f18b72\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6577494 elementor-widget elementor-widget-text-editor\" data-id=\"6577494\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>NEW THERAPIES FOR PEDIATRIC SOLID TUMORS<\/strong><\/p>\n<ul>\n<li>Cell-delivered oncolytic gene therapy (1)<\/li>\n<li>Clinical trial to study a novel oncolytic cell therapy for metastatic or refractory pediatric tumors<\/li>\n<li>Clinical trial to study the feasibility of combining oncolytic virus therapy with standard treatment in children and adolescents with metastatic sarcoma (1)<\/li>\n<li>Clinical trial to study the use of ICOVIR-5 in refractory central nervous system tumors<\/li>\n<\/ul>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ed94d41 elementor-widget elementor-widget-text-editor\" data-id=\"ed94d41\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<pre>(1) Research area funded by    <a href=\"http:\/\/www.asociacionpablougarte.es\/\" target=\"_blank\" rel=\"noopener\"><img decoding=\"async\" class=\"alignnone size-full wp-image-1616\" src=\"https:\/\/drluismadero.com\/archivos\/img\/2018\/02\/logo-apu.png\" alt=\"\" width=\"129\" height=\"50\" \/><\/a><\/pre>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-0652666 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"0652666\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-b004d19\" data-id=\"b004d19\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3dfb6bd elementor-widget elementor-widget-text-editor\" data-id=\"3dfb6bd\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>UMBILICAL CORD MESENCHYMAL STEM CELL THERAPIES<\/strong><\/p>\n<ul>\n<li>Mesenchymal stem cell therapy in Pediatrics<\/li>\n<li>Cerebral palsy in childhood<\/li>\n<li>Graft versus host disease<\/li>\n<li>Osteonecrosis in patients with cancer<\/li>\n<\/ul>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9a2302f elementor-widget elementor-widget-text-editor\" data-id=\"9a2302f\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<pre>Research area funded by    <a href=\"http:\/\/bio-cord.es\/\" target=\"_blank\" rel=\"noopener\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-1615\" src=\"https:\/\/drluismadero.com\/archivos\/img\/2018\/02\/biocord.png\" alt=\"biocord\" width=\"122\" height=\"50\" \/><\/a>   <a href=\"https:\/\/www.sevibe.es\/\" target=\"_blank\" rel=\"noopener\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-1617\" src=\"https:\/\/drluismadero.com\/archivos\/img\/2018\/02\/sevibe.png\" alt=\"sevibe\" width=\"201\" height=\"50\" \/><\/a><\/pre>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-38f1689 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"38f1689\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-7ae38a2\" data-id=\"7ae38a2\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-bf99eef elementor-widget elementor-widget-text-editor\" data-id=\"bf99eef\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>CANCER AND PHYSICAL EXERCISE<\/strong><\/p>\n<ul>\n<li>Physical exercise to improve the performance status of children with cancer<\/li>\n<li>Impact of physical exercise in patients with graft versus host disease<\/li>\n<\/ul>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-026f0d8 elementor-widget elementor-widget-text-editor\" data-id=\"026f0d8\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<pre>Research area funded by    <a href=\"http:\/\/madrid.universidadeuropea.es\" target=\"_blank\" rel=\"noopener\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-1618\" src=\"https:\/\/drluismadero.com\/archivos\/img\/2018\/02\/ue-logo.png\" alt=\"universidad europea\" width=\"194\" height=\"50\" \/><\/a>   <a href=\"https:\/\/aladina.org\/\" target=\"_blank\" rel=\"noopener\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-1614\" src=\"https:\/\/drluismadero.com\/archivos\/img\/2018\/02\/aladina-300x41.png\" alt=\"fundaci\u00f3n aladina\" width=\"300\" height=\"41\" srcset=\"https:\/\/drluismadero.com\/archivos\/img\/2018\/02\/aladina-300x41.png 300w, https:\/\/drluismadero.com\/archivos\/img\/2018\/02\/aladina.png 362w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/a><\/pre>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-a2ea58b elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"a2ea58b\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-895970a\" data-id=\"895970a\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-25bafb8 elementor-widget elementor-widget-text-editor\" data-id=\"25bafb8\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>IMMUNOTHERAPIES FOR THE TREATMENT OF PEDIATRIC SARCOMA<\/strong><\/p>\n<ul>\n<li>Study about the role of immunoediting in sarcomas<\/li>\n<li>Analysis of the immune infiltration in pediatric sarcomas<\/li>\n<li>Combination of immunotherapies (1)<\/li>\n<\/ul>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fb09a6c elementor-widget elementor-widget-text-editor\" data-id=\"fb09a6c\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<pre>(1) Research area funded by    <a href=\"http:\/\/www.asociacionpablougarte.es\/\" target=\"_blank\" rel=\"noopener\"><img decoding=\"async\" class=\"alignnone size-full wp-image-1616\" src=\"https:\/\/drluismadero.com\/archivos\/img\/2018\/02\/logo-apu.png\" alt=\"\" width=\"129\" height=\"50\" \/><\/a><\/pre>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-90b79c7 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"90b79c7\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-74f9b08\" data-id=\"74f9b08\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-27fbbb4 elementor-drop-cap-yes elementor-drop-cap-view-default elementor-widget elementor-widget-text-editor\" data-id=\"27fbbb4\" data-element_type=\"widget\" data-settings=\"{&quot;drop_cap&quot;:&quot;yes&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>TUMOR STEM CELLS IN PEDIATRIC SARCOMA<\/strong><\/p>\n<ul>\n<li>Origin of pediatric bone tumors<\/li>\n<li>Cell subpopulation dynamics in pediatric sarcoma<\/li>\n<\/ul>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-bd2d51b elementor-section-full_width elementor-section-stretched elementor-reverse-mobile elementor-section-height-default elementor-section-height-default\" data-id=\"bd2d51b\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;stretch_section&quot;:&quot;section-stretched&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-6cdd01c\" data-id=\"6cdd01c\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7b393cc elementor-widget elementor-widget-menu-anchor\" data-id=\"7b393cc\" data-element_type=\"widget\" data-widget_type=\"menu-anchor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-menu-anchor\" id=\"proyectos\"><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-149513e elementor-widget elementor-widget-text-editor\" data-id=\"149513e\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Peripheral blood human mesenchymal stem cells: Mobilization, isolation and novel biomarkers.<\/strong><\/p>\n<p>Funding: \u201cFondo de Investigaciones Sanitarias\u201d. File Nr. FIS PI052217<\/p>\n<p>Role: Sub-investigator<\/p>\n<p>Date: 2006-2008<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-10903b6 elementor-widget elementor-widget-text-editor\" data-id=\"10903b6\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Diagnosis of meningeal infiltration in children with acute lymphoblastic leukemia.<\/strong><\/p>\n<ul>\n<li>Funding: \u201cInocente\u201d Foundation<\/li>\n<li>Role: Principal investigator<\/li>\n<li>Date: 2007-2009<\/li>\n<\/ul>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-55cf26b elementor-widget elementor-widget-text-editor\" data-id=\"55cf26b\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Fancogene: Use of molecular biology to develop more efficient diagnostic and therapeutic tools for patients with Fanconi anemia\/BRCA genomes.<\/strong><\/p>\n<ul>\n<li>Funding: \u201cGenoma\u201d Foundation<\/li>\n<li>Role: Principal investigator<\/li>\n<li>Date: 2007-2010<\/li>\n<\/ul>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-197a98d elementor-widget elementor-widget-text-editor\" data-id=\"197a98d\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Celyvir: Oncolytic cell therapy for metastatic neuroblastoma.<\/strong><\/p>\n<ul>\n<li>Funding: \u201cFondo de Investigaciones Sanitarias\u201d. File Nr. ECO7\/90591<\/li>\n<li>Role: Sub-investigator<\/li>\n<li>Date: 2008-2010<\/li>\n<\/ul>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b7555ff elementor-widget elementor-widget-text-editor\" data-id=\"b7555ff\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>ICOVIR-5 in the treatment of relapsed or refractory pediatric central nervous system tumors<\/strong><\/p>\n<ul>\n<li>Funding: \u201cFondo de Investigaciones Sanitarias\u201d. File Nr. ECO8\/00094<\/li>\n<li>Role: Principal investigator<\/li>\n<li>Date: 2009-2011<\/li>\n<\/ul>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b871afa elementor-widget elementor-widget-text-editor\" data-id=\"b871afa\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Production and differentiation of induced pluripotent stem cells (iPS) of patients with genetic diseases of the immune-hematopoietic system<\/strong><\/p>\n<ul>\n<li>Funding: \u201cMinisterio de Ciencia e Innovaci\u00f3n\u201d. File Nr. PLE 2009-0100.<\/li>\n<li>Role: Sub-investigator<\/li>\n<li>Date: 2010-2012<\/li>\n<\/ul>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e0b00b3 elementor-widget elementor-widget-text-editor\" data-id=\"e0b00b3\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Diagnosis of meningeal infiltration in children with central nervous system tumors<\/strong><\/p>\n<ul>\n<li>Funding: \u201cFondo de Investigaciones Sanitarias\u201d. File Nr. PI 10\/02811.<\/li>\n<li>Role: Principal investigator<\/li>\n<li>Date: 2010-2012<\/li>\n<\/ul>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c47e770 elementor-widget elementor-widget-text-editor\" data-id=\"c47e770\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Making medicines out of stem cells: Allogenic ACS and bioengineering for clinical use<\/strong><\/p>\n<ul>\n<li>Funding: \u201cMinisterio de Ciencias e Innovaci\u00f3n\u201d<\/li>\n<li>Role: Sub-investigator<\/li>\n<li>Date: 2010-2012<\/li>\n<\/ul>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9b82dcb elementor-widget elementor-widget-text-editor\" data-id=\"9b82dcb\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Identifying and validating biomarkers for relapsed childhood acute lymphoblastic leukemia<\/strong><\/p>\n<ul>\n<li>Funding: \u201cFondo de Investigaciones Sanitarias.\u201d File Nr. PI13\/02475.<\/li>\n<li>Role: Principal investigator<\/li>\n<li>Date: 2014-2016.<\/li>\n<\/ul>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d1884f7 elementor-widget elementor-widget-text-editor\" data-id=\"d1884f7\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Development of novel targeted therapies for neuroblastoma.<\/strong><\/p>\n<ul>\n<li>Funding: \u201cInocente\u201d Foundation<\/li>\n<li>Role: Sub-investigator<\/li>\n<li>Date: 2015-2016.<\/li>\n<\/ul>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-ff282bf\" data-id=\"ff282bf\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4834ba0 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"4834ba0\" data-element_type=\"widget\" id=\"proin\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"titu\">\n<h2 class=\"min\"><span style=\"font-size: 30px; font-weight: 300;\">RESEARCH<\/span><\/h2>\n<h2 class=\"may\">PROJECTS<\/h2>\n<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1fc87f9 elementor-section-full_width elementor-section-stretched elementor-section-height-default elementor-section-height-default\" data-id=\"1fc87f9\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;stretch_section&quot;:&quot;section-stretched&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-0a2378c\" data-id=\"0a2378c\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f64ace0 animated-slow elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"f64ace0\" data-element_type=\"widget\" id=\"proin\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"titu\">\n<h2 class=\"min\"><span style=\"font-size: 30px; font-weight: 300;\">CLINICAL<\/span><\/h2>\n<h2 class=\"may\">TRIALS<\/h2>\n<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-d4aff1e\" data-id=\"d4aff1e\" data-element_type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d1b195a elementor-widget elementor-widget-menu-anchor\" data-id=\"d1b195a\" data-element_type=\"widget\" data-widget_type=\"menu-anchor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-menu-anchor\" id=\"ensayos\"><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5475542 elementor-widget elementor-widget-heading\" data-id=\"5475542\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">LEUKEMIA AND LYMPHOMA<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-02e4584 elementor-widget elementor-widget-text-editor\" data-id=\"02e4584\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Drug name: <strong>CARFILZOMIB<\/strong><\/p>\n<p>Mechanism of action: Proteasome inhibitor<\/p>\n<p>Trial phase: I-II<\/p>\n<p>Study population: Patients with relapsed precursor B-cell and T-cell ALL, and T-cell lymphoblastic lymphoma<\/p>\n<p>Nr.: 2014-001633-84<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b30750f elementor-widget elementor-widget-text-editor\" data-id=\"b30750f\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Drug name: <strong>IBRUTINIB<\/strong><\/p>\n<p>Mechanism of action: Tyrosine-kinase inhibitor<\/p>\n<p>Trial phase: II<\/p>\n<p>Study population: Mature B-cell lymphoma at first relapse, in combination with \u201cRICE\u201d chemotherapy<\/p>\n<p>Nr.: 2016-000259-28<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1b5b92e elementor-widget elementor-widget-text-editor\" data-id=\"1b5b92e\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Drug name: <strong>NIVOLUMAB + BRENTUXIMAB<\/strong><\/p>\n<p>Mechanism of action: anti-PD1 and anti-CD34<\/p>\n<p>Trial phase: II<\/p>\n<p>Study population: Non-Hodgkin lymphoma at first relpase<\/p>\n<p>Nr.: 02927769<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e53c4d0 elementor-widget elementor-widget-text-editor\" data-id=\"e53c4d0\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Drug name: <strong>BLINATUMOMAB<\/strong><\/p>\n<p>Mechanism of action: Anti-CD19<\/p>\n<p>Trial phase: III<\/p>\n<p>Study population: Precursor B-cell ALL at first high-risk relapse<\/p>\n<p>Nr.: 2014-002476-92<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2588a99 elementor-widget elementor-widget-heading\" data-id=\"2588a99\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">SOLID TUMORS<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d0e4680 elementor-widget elementor-widget-text-editor\" data-id=\"d0e4680\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Drug name: <strong>REGORAFENIB<\/strong><\/p>\n<p>Mechanism of action: Multi tyrosine-kinase inhibitor + Vincristine and Irinotecan<\/p>\n<p>Trial phase: I<\/p>\n<p>Study population: Relapsed\/refractory solid tumors<\/p>\n<p>Nr.: 2013-003579-36<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7f7c015 elementor-widget elementor-widget-text-editor\" data-id=\"7f7c015\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Drug name: <strong>T-VEC<\/strong><\/p>\n<p>Mechanism of action: Oncolytic virus<\/p>\n<p>Trial phase: I<\/p>\n<p>Study population: Relapsed\/refractory extracranial solid tumors, accessible for direct therapeutic injection<\/p>\n<p>Nr.: 2015-003645-25<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8306425 elementor-widget elementor-widget-text-editor\" data-id=\"8306425\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Drug name: <strong>DABRAFENIB<\/strong><\/p>\n<p>Mechanism of action: BRAF inhibitor<\/p>\n<p>Trial phase: I-II<\/p>\n<p>Study population: Relapsed\/refractory high grade glioma, melanoma or thyroid cancer<\/p>\n<p>Nr.: 2012-001499-12<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4d55be5 elementor-widget elementor-widget-text-editor\" data-id=\"4d55be5\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Drug name: <strong>COBIMETINIB<\/strong><\/p>\n<p>Mechanism of action: MEK inhibitor<\/p>\n<p>Trial phase: I-II<\/p>\n<p>Study population: Relapsed or refractory solid tumors (glioma, DIPG, rhabdomyosarcoma, neuroblastoma, melanoma, rhabdoid tumors, NF-1 linked tumors and other tumors with RAS\/RAF\/MEK\/ERK activity).<\/p>\n<p>Nr.: 2014-004685-25<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-20b4e4e elementor-widget elementor-widget-text-editor\" data-id=\"20b4e4e\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Drug name: <strong>ABRAXANE<\/strong><\/p>\n<p>Mechanism of action: Nab-paclitaxel<\/p>\n<p>Trial phase: II<\/p>\n<p>Study population:<\/p>\n<p>First cohort: Relapsed\/refractory desmoid tumors<\/p>\n<p>Second cohort: Relapsed\/refractory Ewing sarcoma<\/p>\n<p>Relpased\/refractory desmoplastic small-round-cell tumors<\/p>\n<p>Nr.: 2013-000144-26<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e60712f elementor-widget elementor-widget-text-editor\" data-id=\"e60712f\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Drug name: <strong>PAZOPANIB<\/strong><\/p>\n<p>Mechanism of action: VEGF inhibitor<\/p>\n<p>Trial phase: II<\/p>\n<p>Study population: Refractory solid tumors (rhabdomyosarcoma, non-rhabdomyosarcoma soft tissue sarcoma, Ewing\/PNET sarcoma, osteosarcoma, neuroblastoma, hepatoblastoma)<\/p>\n<p>Nr.: 2013-003595-12<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-152295c elementor-widget elementor-widget-text-editor\" data-id=\"152295c\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Drug name: <strong>BEACON<\/strong><\/p>\n<p>Mechanism of action: VEGFR inhibitor +\/-:<\/p>\n<p>Temozolomide<\/p>\n<p>Irinotecan-temozolomide<\/p>\n<p>Topotecan-temozolomide<\/p>\n<p>Trial phase: II<\/p>\n<p>Study population: Relapsed\/refractory neuroblastoma<\/p>\n<p>Nr.: 2012-000072-42<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a3c624c elementor-widget elementor-widget-text-editor\" data-id=\"a3c624c\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Drug name: <strong>LENVATINIB<\/strong><\/p>\n<p>Mechanism of action: VEGFR inhibitor as single treatment or in combination with ifosfamide + etoposide<\/p>\n<p>Trial phase: I-II<\/p>\n<p>Study population: Relapsed\/refractory osteosarcoma and differentiated thyroid cancer<\/p>\n<p>Nr.: 2013-005534-38<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2554728 elementor-widget elementor-widget-text-editor\" data-id=\"2554728\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Drug name: <strong>NIVOLUMAB +\/- IPILIMUMAB<\/strong><\/p>\n<p>Mechanism of action: Anti-PD1 and anti-CTLA4 immunotherapy<\/p>\n<p>Trial phase: II<\/p>\n<p>Study population: CNS tumors (DIPG, medulloblastoma, ependymoma, high grade glioma and other high grade CNS tumors)<\/p>\n<p>Nr.: 2016-004441-82<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5ca85c9 elementor-widget elementor-widget-text-editor\" data-id=\"5ca85c9\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Drug name: <strong>POMALIDOMIDE<\/strong><\/p>\n<p>Mechanism of action: Immunomodulation and anti-angiogenesis<\/p>\n<p>Trial phase: II<\/p>\n<p>Study population: Pediatric patients with CNS tumors (DIPG, medulloblastoma, ependymoma and high grade glioma)<\/p>\n<p>Nr.: 2016-002903-25<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bb95d22 elementor-widget elementor-widget-text-editor\" data-id=\"bb95d22\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Drug name: <strong>M<sub>14<\/sub>-483 EGFR ANTIBODY DRUG CONJUGATE ABVIE<\/strong><\/p>\n<p>Mechanism of action: EGFR inhibitor<\/p>\n<p>Trial phase: II<\/p>\n<p>Study population: CNS tumors with EGFR amplification (high grade glioma, DIPG); single therapy or in combination with temozolomide.<\/p>\n<p>Nr.: 2014-004438-24<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>RESEARCH Dr. Luis Maderoleads cancer research at Children\u2019s University Hospital \u201cNi\u00f1o Jes\u00fas\u201d, Madrid University Hospital \u201cNi\u00f1o Jes\u00fas\u201d is a national and international reference center for the diagnosis and treatment of children with cancer. Some of the research areas include childhood leukemia, cell and oncolytic immunotherapy for metastatic or refractory pediatric tumors, physical exercise in children &#8230; <\/p>\n<p class=\"read-more-container\"><a title=\"RESEARCH\" class=\"read-more button\" href=\"https:\/\/drluismadero.com\/en\/pediatric-oncology\/research\/#more-2622\" aria-label=\"Read more about RESEARCH\">Leer m\u00e1s<\/a><\/p>\n","protected":false},"author":455,"featured_media":0,"parent":2584,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"generate_page_header":"","footnotes":""},"class_list":["post-2622","page","type-page","status-publish"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.1.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>RESEARCH - DR. 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